Understanding the impact of production, bar drain board environmental exposure and age characteristics on the reliability of a population is frequently based on underlying science and empirical assessment.When there is incomplete science to prescribe which inputs should be included in a model of reliability to predict future trends, statistical mod
The treatment of blast phase chronic myeloid leukemia (bpCML) remains a challenge due at least in part to drug resistance of leukemia stem cells (LSCs).Recent clinical evidence suggests that the BCL-2 inhibitor venetoclax in combination with ABL-targeting tyrosine kinase inhibitors (TKIs) can eradicate bpCML LSCs.In this report, we employed preclin
Osteoarthritis (OA) is the most common joint pathology causing severe pain and disability.Macrophages play a central role in the pathogenesis of OA.In the joint microenvironment, macrophages with an M1-like pro-inflammatory phenotype induce chronic inflammation and joint destruction, and they have been correlated with the development and progressio
**Background:** The opioid epidemic has disproportionately affected several areas across the United States (US), with research indicating that these areas may be underserved and lack access to sufficient medication-assisted treatment (MAT) options.The objective of this study was to introduce a geospatial analytical framework for identifying sub-sta
Hepatocellular carcinoma(HCC) is the sixth most common cancer in the world and is usually caused by viral hepatitis (HBV and HCV), alcoholic, and non-alcoholic fatty liver disease(NAFLD).Viral hepatitis accounts for 80% of HCC cases worldwide.In addition, With the increasing incidence of metabolic diseases, NAFLD is now the most common liver diseas